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Target
Mu-type opioid receptor
Ligand
BDBM472075
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
1.20±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472075
Synonyms:
CIS-3-[[1-(Cyclobutyl-methyl)-8-dimethylamino-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-methyl]-benzonitrile | US10829480, Example SC_2081
Type:
Small organic molecule
Emp. Form.:
C29H36N4O
Mol. Mass.:
456.6223
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)C#N)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.21,3.2,(-5.62,-.45,;-4.85,-1.78,;-3.31,-1.78,;-5.62,-3.12,;-6.39,-4.45,;-7.93,-4.45,;-8.7,-3.12,;-9.61,-1.87,;-11.07,-2.35,;-12.4,-1.58,;-13.74,-2.35,;-13.74,-3.89,;-15.07,-4.66,;-16.4,-3.89,;-16.4,-2.35,;-15.07,-1.58,;-17.74,-1.58,;-19.07,-.81,;-11.07,-3.89,;-12.4,-4.66,;-9.61,-4.36,;-9.21,-5.85,;-10.3,-6.94,;-11.84,-6.94,;-11.84,-8.48,;-10.3,-8.48,;-7.93,-1.78,;-6.39,-1.78,;-4.85,-4.45,;-5.62,-5.79,;-4.85,-7.12,;-3.31,-7.12,;-2.54,-5.79,;-3.31,-4.45,)|
Structure:
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