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Target
Mu-type opioid receptor
Ligand
BDBM472085
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
3.50±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472085
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-8-phenyl-3-[[6-(trifluoromethyl)- pyridin-3-yl]-methyl]-1,3-diazaspiro[4.5]decan-2-one | US10829480, Example SC_2086
Type:
Small organic molecule
Emp. Form.:
C28H35F3N4O
Mol. Mass.:
500.5989
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3ccc(nc3)C(F)(F)F)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(-7.61,15.44,;-6.84,14.1,;-5.3,14.1,;-7.61,12.77,;-8.38,11.44,;-9.92,11.44,;-10.69,12.77,;-11.6,14.02,;-13.06,13.54,;-14.39,14.31,;-15.73,13.54,;-17.06,14.31,;-18.39,13.54,;-18.39,12,;-17.06,11.23,;-15.73,12,;-19.73,11.23,;-21.06,10.46,;-19.73,9.69,;-21.06,12,;-13.06,12,;-14.39,11.23,;-11.6,11.52,;-11.2,10.04,;-12.29,8.95,;-13.83,8.95,;-13.83,7.41,;-12.29,7.41,;-9.92,14.1,;-8.38,14.1,;-6.84,11.44,;-7.61,10.1,;-6.84,8.77,;-5.3,8.77,;-4.53,10.1,;-5.3,11.44,)|
Structure:
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