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Target
Mu-type opioid receptor
Ligand
BDBM472098
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
0.800±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472098
Synonyms:
CIS-1-(Cyclobutyl-methyl)-8-dimethylamino-3-[(3-methylsulfonyl-phenyl)-methyl]- 8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10829480, Example SC_2093
Type:
Small organic molecule
Emp. Form.:
C29H39N3O3S
Mol. Mass.:
509.703
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3cccc(c3)S(C)(=O)=O)C(=O)N2CC2CCC2)CC1)c1ccccc1 |r,wU:6.23,3.2,(16.32,28.25,;17.09,26.91,;18.63,26.91,;16.32,25.58,;15.55,24.25,;14.01,24.25,;13.24,25.58,;12.34,26.82,;10.87,26.35,;9.54,27.12,;8.2,26.35,;8.2,24.81,;6.87,24.04,;5.54,24.81,;5.54,26.35,;6.87,27.12,;4.2,27.12,;2.87,26.35,;2.87,27.89,;5.54,27.89,;10.87,24.81,;9.54,24.04,;12.34,24.33,;12.73,22.85,;11.65,21.76,;10.11,21.76,;10.11,20.22,;11.65,20.22,;14.01,26.91,;15.55,26.91,;17.09,24.25,;16.32,22.91,;17.09,21.58,;18.63,21.58,;19.4,22.91,;18.63,24.25,)|
Structure:
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