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Target
Mu-type opioid receptor
Ligand
BDBM472102
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
11.2±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472102
Synonyms:
CIS-8-Dimethylamino-3-[(4-methoxyphenyl)-methyl]-8-phenyl-1-propyl-1,3- diazaspiro[4.5]decan-2-one | US10829480, Example SC_2095
Type:
Small organic molecule
Emp. Form.:
C27H37N3O2
Mol. Mass.:
435.6016
SMILES:
CCCN1C(=O)N(Cc2ccc(OC)cc2)C[C@]11CC[C@@](CC1)(N(C)C)c1ccccc1 |r,wU:17.18,20.25,(11.81,8.18,;11.42,9.67,;12.5,10.76,;12.11,12.25,;10.64,12.72,;9.31,11.95,;10.64,14.26,;9.31,15.03,;7.97,14.26,;6.64,15.03,;5.31,14.26,;5.31,12.72,;3.97,11.95,;2.64,12.72,;6.64,11.95,;7.97,12.72,;12.11,14.74,;13.01,13.49,;13.78,12.16,;15.32,12.16,;16.09,13.49,;15.32,14.83,;13.78,14.83,;16.86,14.83,;16.09,16.16,;18.4,14.83,;16.86,12.16,;16.09,10.83,;16.86,9.49,;18.4,9.49,;19.17,10.83,;18.4,12.16,)|
Structure:
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