Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM472117
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
12.5±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472117
Synonyms:
CIS-2-[4-[[8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-2-oxo-8-phenyl-1,3- diazaspiro[4.5]decan-3-yl]-methyl-1H-[1,2,3]triazol-1-yl]-acetamide | US10829480, Example SC_2155
Type:
Small organic molecule
Emp. Form.:
C26H37N7O3
Mol. Mass.:
495.6171
SMILES:
CN(C)[C@]1(CC[C@]2(CN(Cc3cn(CC(N)=O)nn3)C(=O)N2CC2(O)CCC2)CC1)c1ccccc1 |r,wU:6.22,3.2,(16.97,-2.14,;17.74,-3.48,;19.28,-3.48,;16.97,-4.81,;16.2,-6.14,;14.66,-6.14,;13.89,-4.81,;12.98,-3.56,;11.52,-4.04,;10.19,-3.27,;8.85,-4.04,;7.44,-3.41,;6.41,-4.56,;4.93,-4.16,;3.84,-5.25,;2.35,-4.85,;4.24,-6.74,;7.18,-5.89,;8.69,-5.57,;11.52,-5.58,;10.19,-6.35,;12.98,-6.06,;13.38,-7.54,;12.29,-8.63,;11.52,-7.3,;10.75,-8.63,;10.75,-10.17,;12.29,-10.17,;14.66,-3.48,;16.2,-3.48,;17.74,-6.14,;16.97,-7.48,;17.74,-8.81,;19.28,-8.81,;20.05,-7.48,;19.28,-6.14,)|
Structure:
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