Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM472139
Substrate
n/a
Meas. Tech.
Receptor Binding Assay
Ki
8.15±n/a nM
Citation
 Kuehnert, S; Koenigs, RM; Kless, A; Wegert, A; Ratcliffe, P; Jostock, R; Koch, T; Linz, K; Schroeder, W; Schiene, K; Konetzki, I 3-((hetero-)aryl)-alkyl-8-amino-2-oxo-l,3-diaza-spiro-[4.5]-decane derivatives US Patent  US10829480 Publication Date 11/10/2020 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM472139
Synonyms:
CIS-8-Dimethylamino-1-[(1-hydroxy-cyclobutyl)-methyl]-3-(1-methyl-l-phenyl- ethyl)-8-phenyl-1,3-diazaspiro[4.5]decan-2-one | US10829480, Example SC_2174
Type:
Small organic molecule
Emp. Form.:
C30H41N3O2
Mol. Mass.:
475.6654
SMILES:
CN(C)[C@]1(CC[C@]2(CN(C(=O)N2CC2(O)CCC2)C(C)(C)c2ccccc2)CC1)c1ccccc1 |r,wU:6.11,3.2,(-6.23,15.33,;-6.23,13.79,;-4.9,13.02,;-7.57,13.02,;-8.34,11.69,;-9.88,11.69,;-10.65,13.02,;-11.55,14.27,;-13.02,13.79,;-13.02,12.25,;-14.35,11.48,;-11.55,11.77,;-11.15,10.29,;-12.24,9.2,;-10.91,8.43,;-13.78,9.2,;-13.78,7.66,;-12.24,7.66,;-14.1,14.88,;-14.5,16.37,;-13.02,15.97,;-15.59,14.48,;-16.68,15.57,;-18.17,15.17,;-18.57,13.68,;-17.48,12.59,;-15.99,12.99,;-9.88,14.35,;-8.34,14.35,;-6.8,11.69,;-7.57,10.35,;-6.8,9.02,;-5.26,9.02,;-4.49,10.35,;-5.26,11.69,)|
Structure:
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