Target
Nuclear receptor ROR-gamma
Ligand
BDBM472295
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
>1000±n/a nM
Citation
 Claremon, DADillard, LWFan, YLotesta, SDSingh, SBTice, CMZhao, WZhuang, L Benzimidazole derivatives as modulators of ROR-gamma US Patent  US10829481 Publication Date 11/10/2020 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM472295
Synonyms:
2-cyclopropyl-N-(4-(ethylsulfonyl)benzyl)-1-((1-(2,2,2-trifluoroethyl)- | US10829481, Compound I-111
Type:
Small organic molecule
Emp. Form.:
C26H26F3N5O3S
Mol. Mass.:
545.577
SMILES:
CCS(=O)(=O)c1ccc(CNC(=O)c2ccc3n(Cc4cnn(CC(F)(F)F)c4)c(nc3c2)C2CC2)cc1
Structure:
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