Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472397
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
<500±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472397
Synonyms:
US10829483, Compound WX005
Type:
Small organic molecule
Emp. Form.:
C20H20BrN3O2S2
Mol. Mass.:
478.426
SMILES:
CC(C)(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccccc1)C(O)=O |(2.15,5.5,;2.55,4.01,;3.64,5.1,;1.46,2.92,;-.03,3.32,;-.5,4.78,;-2.04,4.78,;-2.52,3.32,;-3.85,2.55,;-1.27,2.41,;-1.27,.87,;-2.52,-.03,;-2.04,-1.5,;-.5,-1.5,;.53,-2.64,;2.03,-2.32,;2.51,-.86,;1.48,.29,;-.03,-.03,;-2.81,-2.83,;-4.35,-2.83,;-5.12,-4.16,;-4.35,-5.5,;-2.81,-5.5,;-2.04,-4.16,;4.04,3.61,;5.12,4.7,;4.43,2.12,)|
Structure:
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