Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472400
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
2750±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472400
Synonyms:
US10829483, Compound WX008
Type:
Small organic molecule
Emp. Form.:
C18H14BrF2N3O2S2
Mol. Mass.:
486.353
SMILES:
OC(=O)CSc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(F)c(F)c1 |(5.89,5.72,;4.81,4.63,;5.2,3.15,;3.32,5.03,;2.23,3.94,;.74,4.34,;.27,5.81,;-1.27,5.81,;-1.75,4.34,;-3.08,3.57,;-.5,3.44,;-.5,1.9,;-1.75,.99,;-1.27,-.47,;.27,-.47,;1.3,-1.62,;2.8,-1.3,;3.28,.17,;2.25,1.31,;.74,.99,;-2.04,-1.81,;-1.27,-3.14,;-2.04,-4.47,;-3.58,-4.47,;-4.35,-5.81,;-4.35,-3.14,;-5.89,-3.14,;-3.58,-1.81,)|
Structure:
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