Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472402
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
2750±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472402
Synonyms:
US10829483, Compound WX010
Type:
Small organic molecule
Emp. Form.:
C21H19BrF3N3O2S2
Mol. Mass.:
546.424
SMILES:
CC(C)(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |(1.46,5.77,;2.55,4.68,;2.95,6.16,;1.46,3.59,;-.03,3.99,;-.5,5.45,;-2.04,5.45,;-2.52,3.99,;-3.85,3.22,;-1.27,3.08,;-1.27,1.54,;-2.52,.64,;-2.04,-.83,;-.5,-.83,;.53,-1.97,;2.03,-1.65,;2.51,-.19,;1.48,.96,;-.03,.64,;-2.81,-2.16,;-4.35,-2.16,;-5.12,-3.5,;-4.35,-4.83,;-2.81,-4.83,;-2.04,-3.5,;-5.12,-6.16,;-6.66,-6.16,;-4.35,-7.5,;-5.89,-7.5,;4.04,4.28,;5.12,5.37,;4.43,2.79,)|
Structure:
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