Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472407
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>5000±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472407
Synonyms:
US10829483, Compound WX015
Type:
Small organic molecule
Emp. Form.:
C20H20BrN3O4S3
Mol. Mass.:
542.489
SMILES:
CC(Sc1nnc(Br)n1-c1sc(c2CCCCc12)-c1ccc(cc1)S(C)(=O)=O)C(O)=O |(2.92,6.55,;3.32,5.06,;2.23,3.97,;.74,4.37,;.27,5.84,;-1.27,5.84,;-1.75,4.37,;-3.08,3.6,;-.5,3.47,;-.5,1.93,;-1.75,1.02,;-1.27,-.44,;.27,-.44,;1.3,-1.59,;2.8,-1.27,;3.28,.2,;2.25,1.34,;.74,1.02,;-2.04,-1.78,;-3.58,-1.78,;-4.35,-3.11,;-3.61,-4.49,;-2.04,-4.45,;-1.27,-3.11,;-4.38,-5.83,;-5.15,-7.16,;-5.72,-5.06,;-3.05,-6.6,;4.81,4.66,;5.89,5.75,;5.2,3.18,)|
Structure:
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