Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472422
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
<500±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472422
Synonyms:
US10829483, Compound WX027
Type:
Small organic molecule
Emp. Form.:
C17H20BrN3O2S2
Mol. Mass.:
442.394
SMILES:
CC(C)(Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCCc12)C(O)=O |(1.66,4.93,;2.06,3.45,;2.83,4.78,;.97,2.36,;-.52,2.76,;-.99,4.22,;-2.53,4.22,;-3.01,2.76,;-4.34,1.99,;-1.76,1.85,;-1.76,.31,;-3.01,-.59,;-2.53,-2.06,;-3.3,-3.39,;-4.64,-4.16,;-3.3,-4.93,;-.99,-2.06,;.04,-3.2,;1.54,-2.88,;2.02,-1.42,;.99,-.27,;-.52,-.59,;3.55,3.05,;4.64,4.14,;3.95,1.56,)|
Structure:
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