Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472450
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>5000±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472450
Synonyms:
US10829483, Compound WX047
Type:
Small organic molecule
Emp. Form.:
C15H14BrN5O2S2
Mol. Mass.:
440.338
SMILES:
Cn1cc(cn1)-c1sc(c2CCCc12)-n1c(Br)nnc1SCC(O)=O |(.74,-5.76,;.74,-4.22,;-.5,-3.32,;-.03,-1.85,;1.51,-1.85,;1.99,-3.32,;-.8,-.52,;-.32,.95,;-1.57,1.85,;-2.81,.95,;-4.35,.95,;-4.83,-.52,;-3.58,-1.42,;-2.34,-.52,;-1.57,3.39,;-2.81,4.3,;-4.15,3.53,;-2.34,5.76,;-.8,5.76,;-.32,4.3,;1.16,3.9,;2.25,4.99,;3.74,4.59,;4.83,5.68,;4.14,3.1,)|
Structure:
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