Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472466
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>5000±n/a nM
Citation
Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent US10829483 Publication Date 11/10/2020
More Info.:
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
Inhibitor
Name:
BDBM472466
Synonyms:
US10829483, Compound WX058
Type:
Small organic molecule
Emp. Form.:
C14H14BrN3O2S2
Mol. Mass.:
400.314
SMILES:
OC(=O)CSc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12 |(4.83,4.49,;3.74,3.4,;4.14,1.92,;2.25,3.8,;1.16,2.71,;-.32,3.11,;-.8,4.58,;-2.34,4.58,;-2.81,3.11,;-4.15,2.34,;-1.57,2.21,;-1.57,.67,;-.32,-.24,;-.8,-1.7,;-.03,-3.04,;-.03,-4.58,;1.31,-3.81,;-2.34,-1.7,;-3.58,-2.61,;-4.83,-1.7,;-4.35,-.24,;-2.81,-.24,)|