Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472468
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
<500±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472468
Synonyms:
US10829483, Compound WX060
Type:
Small organic molecule
Emp. Form.:
C18H20BrN3O2S2
Mol. Mass.:
454.404
SMILES:
OC(=O)C1(CCCC1)Sc1nnc(Br)n1-c1sc(C2CC2)c2CCCc12 |(5.7,2.4,;4.37,1.63,;4.37,.09,;3.03,2.4,;4.28,3.31,;3.8,4.77,;2.26,4.77,;1.79,3.31,;1.7,1.63,;.37,2.4,;.37,3.94,;-1.1,4.42,;-2,3.17,;-3.54,3.17,;-1.1,1.93,;-1.87,.59,;-.96,-.65,;-1.87,-1.9,;-1.1,-3.23,;-1.1,-4.77,;.24,-4,;-3.33,-1.42,;-4.8,-1.9,;-5.7,-.65,;-4.8,.59,;-3.33,.12,)|
Structure:
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