Reaction Details Report a problem with these data
Target
Solute carrier family 22 member 12
Ligand
BDBM472518
Substrate
n/a
Meas. Tech.
In Vitro Inhibitory Activity Assay
IC50
>5000±n/a nM
Citation
 Wang, J; Zhang, Y; Zhu, W; Chen, S Thiophene, manufacturing method thereof, and pharmaceutical application of same US Patent  US10829483 Publication Date 11/10/2020 
Target
Name:
Solute carrier family 22 member 12
Synonyms:
OATL4 | Organic anion transporter 4-like protein | RST | Renal-specific transporter | S22AC_HUMAN | SLC22A12 | Solute carrier family 22 member 12 | Solute carrier family 22 member 12 (URAT1) | URAT1 | Urate anion exchanger 1 | Urate anion exchanger 1 (URAT1) | Uric Acid Transporter 1 (URAT1)
Type:
Enzyme
Mol. Mass.:
59638.65
Organism:
Homo sapiens (Human)
Description:
Q96S37
Residue:
553
Sequence:
MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
  
Inhibitor
Name:
BDBM472518
Synonyms:
US10829483, Compound WX101
Type:
Small organic molecule
Emp. Form.:
C17H21N3O2S2
Mol. Mass.:
363.498
SMILES:
CC(C)c1nnc(SCC(O)=O)n1-c1sc(C2CC2)c2CCCc12 |(-5.11,3.8,;-4.02,2.71,;-4.42,1.23,;-2.53,3.11,;-2.06,4.58,;-.52,4.58,;-.04,3.11,;1.45,2.71,;2.53,3.8,;4.02,3.4,;5.11,4.49,;4.42,1.92,;-1.29,2.21,;-1.29,.67,;-.04,-.24,;-.52,-1.7,;.25,-3.04,;.25,-4.58,;1.59,-3.81,;-2.06,-1.7,;-3.3,-2.61,;-4.55,-1.7,;-4.07,-.24,;-2.53,-.24,)|
Structure:
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