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Target
Bcl-2-like protein 11 [81-106]
Ligand
BDBM472685
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
14.0±n/a nM
Citation
 Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors US Patent  US10829488 Publication Date 11/10/2020 
Target
Name:
Bcl-2-like protein 11 [81-106]
Synonyms:
B2L11_HUMAN | BCL2L11 | BIM | Bcl-2-like protein 11 (BIM)(81-106)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
2973.28
Organism:
Homo sapiens (Human)
Description:
aa 81-106
Residue:
26
Sequence:
IFMRRSSLLSRSSSGYFSFDTDRSPA
  
Inhibitor
Name:
BDBM472685
Synonyms:
(R)-N-((4-(((1,4-dioxan-2-yl)methyl)amino)-3- nitrophenyl)sulfonyl)-2-((1H-pyrrolo[2,3-b] pyridin-5-yl)oxy)-4-(1-((6-(4-chlorophenyl)-2- oxaspiro[3.5]non-6-en-7-yl)methyl)-1,2,3,6- tetrahydropyridin-4-yl)benzamide | US10829488, Cpd. No. 5
Type:
Small organic molecule
Emp. Form.:
C45H45ClN6O9S
Mol. Mass.:
881.392
SMILES:
[O-][N+](=O)c1cc(ccc1NC[C@@H]1COCCO1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)C1=CCN(CC2=C(CC3(COC3)CC2)c2ccc(Cl)cc2)CC1 |r,t:44,49|
Structure:
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