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Target
Bcl-2-like protein 11 [72-87]
Ligand
BDBM361583
Substrate
n/a
Meas. Tech.
Fluorescence Polarization Assay
IC50
4.40±n/a nM
Citation
 Wang, S; Chen, J N-(phenylsulfonyl)benzamides and related compounds as bcl-2 inhibitors US Patent  US10829488 Publication Date 11/10/2020 
Target
Name:
Bcl-2-like protein 11 [72-87]
Synonyms:
B2L11_HUMAN | BCL2L11 | BIM | Bcl-2 homologous antagonist/killer (BAK)(72-87)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
1724.92
Organism:
Homo sapiens (Human)
Description:
aa 72-87
Residue:
16
Sequence:
GQVGRQLAIIGDDINR
  
Inhibitor
Name:
BDBM361583
Synonyms:
2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(1-((6-(4- chlorophenyl)spiro[3.5]non-6-en-7- yl)methyl)piperidin-4-yl)-N-((3-nitro-4-(((tetrahydro- 2H-pyran-4- yl)methyl)amino)phenyl)sulfonyl)benzamide | US10221174, Compound 12 | US10829488, Compound 12 | US11718613, Compound 12
Type:
Small organic molecule
Emp. Form.:
C47H51ClN6O7S
Mol. Mass.:
879.462
SMILES:
[O-][N+](=O)c1cc(ccc1NCC1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)C1CCN(CC2=C(CC3(CCC3)CC2)c2ccc(Cl)cc2)CC1 |t:49|
Structure:
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