Target
High affinity nerve growth factor receptor
Ligand
BDBM472734
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
<1.000±n/a nM
Citation
 Zhu, LHu, YWu, WDai, LDuan, XYang, YSun, YHan, YPeng, YKong, FLuo, HYang, LXu, HGuo, MZhong, ZWang, S Amino pyrazolopyrimidine compound used as neurotrophic factor tyrosine kinase receptor inhibitor US Patent  US10829492 Publication Date 11/10/2020 
Target
Name:
High affinity nerve growth factor receptor
Synonyms:
2.7.10.1 | MTC | NTRK1 | NTRK1/NTRK2 | NTRK1_HUMAN | Nerve growth factor receptor Trk-A | Neurotrophic tyrosine kinase receptor type 1 | Neurotrophic tyrosine kinase receptor type 1 (TrkA) | Synonyms=MTC | TRK | TRK1-transforming tyrosine kinase protein | TRKA | TRKA GN | Trk-A | Tropomyosin alpha-3 chain/High affinity nerve growth factor receptor | Tropomyosin-related kinase A | Tropomyosin-related kinase A (TrkA) | Tyrosine kinase receptor | Tyrosine kinase receptor (Trk) | Tyrosine kinase receptor A | Tyrosine kinase receptor A (Trk A) | Tyrosine kinase receptor A (Trk-A) | Tyrosine kinase receptor A (TrkA) | gp140trk | p140-TrkA
Type:
n/a
Mol. Mass.:
87498.18
Organism:
Homo sapiens (Human)
Description:
P04629
Residue:
796
Sequence:
MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG
  
Inhibitor
Name:
BDBM472734
Synonyms:
(R)-2-amino-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(4-hydroxycyclohexyl)pyrazolo[1,5-c]pyrimidine-3-carboxamide | US10829492, Example 11
Type:
Small organic molecule
Emp. Form.:
C23H26F2N6O2
Mol. Mass.:
456.4883
SMILES:
Nc1nn2ccc(nc2c1C(=O)NC1CCC(O)CC1)N1CCC[C@@H]1c1cc(F)ccc1F |r,wD:24.28,(2.64,3.82,;1.3,3.05,;-.11,3.68,;-1.14,2.53,;-2.68,2.53,;-3.45,1.2,;-2.68,-.13,;-1.14,-.13,;-.37,1.2,;1.14,1.52,;2.29,.49,;1.97,-1.02,;3.75,.97,;4.89,-.07,;4.57,-1.57,;5.72,-2.6,;7.18,-2.13,;8.33,-3.16,;7.5,-.62,;6.36,.41,;-3.45,-1.47,;-2.97,-2.93,;-4.22,-3.84,;-5.46,-2.93,;-4.99,-1.47,;-5.89,-.22,;-5.26,1.18,;-6.17,2.43,;-5.54,3.84,;-7.7,2.27,;-8.33,.86,;-7.42,-.38,;-8.05,-1.79,)|
Structure:
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