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Target
Beta-arrestin-1
Ligand
BDBM472835
Substrate
n/a
Meas. Tech.
beta-Arrestin Assay
EC50
3100±n/a nM
Citation
 Tounge, BA; Bayoumy, S; Kuo, LC; Dax, SL Substituted 3-dialkylaminomethyl-piperidin-4-yl-benzamides and methods of making and using same US Patent  US10836728 Publication Date 11/17/2020 
Target
Name:
Beta-arrestin-1
Synonyms:
ARR1 | ARRB1 | ARRB1_HUMAN | Arrestin, beta 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47062.57
Organism:
Homo sapiens (Human)
Description:
gi_13177715
Residue:
418
Sequence:
MGDKGTRVFKKASPNGKLTVYLGKRDFVDHIDLVDPVDGVVLVDPEYLKERRVYVTLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLIKKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLEEKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDKEIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAMEEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTLLREGANREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKEEPPHREVPENETPVDTNLIELDTNDDDIVFEDFARQRLKGMKDDKEEEEDGTGSPQLNNR
  
Inhibitor
Name:
BDBM472835
Synonyms:
3-(3-((Dimethylamino)methyl)-4-hydroxy-1-(4-hydroxyphenethyl) piperidin-4-yl)benzamide | US10836728, Compound (18)
Type:
Small organic molecule
Emp. Form.:
C23H31N3O3
Mol. Mass.:
397.5105
SMILES:
CN(C)CC1CN(CCc2ccc(O)cc2)CCC1(O)c1cccc(c1)C(N)=O
Structure:
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