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Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM473005
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
1600±n/a nM
Citation
 Semple, G; Ren, AS; Schrader, TO; Kasem, M; Zhu, X 5-HT2C receptor agonists and compositions and methods of use US Patent  US10836764 Publication Date 11/17/2020 
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-2C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQCDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM473005
Synonyms:
(R)-4-chloro-2-(methylthio)-5,6,6a,7,8,9,10,11- octahydropyrimido[5',4':5,6]pyrido[1,2- a][1,4]diazepine | US10836764, Compound 159
Type:
Small organic molecule
Emp. Form.:
C12H17ClN4S
Mol. Mass.:
284.808
SMILES:
CSc1nc(Cl)c2CC[C@@H]3CNCCCN3c2n1 |r|
Structure:
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