Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM473005
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
12300±n/a nM
Citation
 Semple, G; Ren, AS; Schrader, TO; Kasem, M; Zhu, X 5-HT2C receptor agonists and compositions and methods of use US Patent  US10836764 Publication Date 11/17/2020 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2A | 5-hydroxytryptamine receptor 2A (5-HT-2A) | 5-hydroxytryptamine receptor 2A (5HT-2A) | 5-hydroxytryptamine receptor 2A (5HT2A) | 5HT2A_HUMAN | HTR2 | HTR2A | Serotonin receptor 2A
Type:
undefined
Mol. Mass.:
52607.65
Organism:
Homo sapiens (Human)
Description:
P28223
Residue:
471
Sequence:
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
  
Inhibitor
Name:
BDBM473005
Synonyms:
(R)-4-chloro-2-(methylthio)-5,6,6a,7,8,9,10,11- octahydropyrimido[5',4':5,6]pyrido[1,2- a][1,4]diazepine | US10836764, Compound 159
Type:
Small organic molecule
Emp. Form.:
C12H17ClN4S
Mol. Mass.:
284.808
SMILES:
CSc1nc(Cl)c2CC[C@@H]3CNCCCN3c2n1 |r|
Structure:
Search PDB for entries with ligand similarity: