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Target
5-hydroxytryptamine receptor 2B
Ligand
BDBM473014
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
331±n/a nM
Citation
 Semple, G; Ren, AS; Schrader, TO; Kasem, M; Zhu, X 5-HT2C receptor agonists and compositions and methods of use US Patent  US10836764 Publication Date 11/17/2020 
Target
Name:
5-hydroxytryptamine receptor 2B
Synonyms:
5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
54312.47
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:
481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
  
Inhibitor
Name:
BDBM473014
Synonyms:
(R)-8-methyl-4-(3,3,3-trifluoropropyl)- 6,6a,7,8,9,10-hexahydro-5H-pyrazino[1,2- a][1,8]naphthyridine | US10836764, Compound 168
Type:
Small organic molecule
Emp. Form.:
C15H20F3N3
Mol. Mass.:
299.3346
SMILES:
CN1CCN2[C@H](CCc3c(CCC(F)(F)F)ccnc23)C1 |r|
Structure:
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