Reaction Details Report a problem with these data
Target
Capsid protein
Ligand
BDBM473023
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
33.2±n/a nM
Citation
 Gutierrez, DA; Kobayashi, T; Lazerwith, SE; Lee, RA; Morganelli, PA; Pyun, H Substituted pyrrolizine compounds and uses thereof US Patent  US10836769 Publication Date 11/17/2020 
Target
Name:
Capsid protein
Synonyms:
C | CAPSD_HBVCJ | Core antigen | Core protein | HBcAg | p21.5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21105.01
Organism:
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C)
Description:
n/a
Residue:
183
Sequence:
MDIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
  
Inhibitor
Name:
BDBM473023
Synonyms:
5-(2(3,3-difluoro-1-(1-methyl-1H-1,2,3-triazol-4-yl)cyclobutyl)amino)-2-oxoacetyl)-N-(4-fluorophenyl)-6-methyl-2,3-dihydro-1H-pyrrolizine-7-carboxamide | US10836769, Example 10
Type:
Small organic molecule
Emp. Form.:
C24H23F3N6O3
Mol. Mass.:
500.473
SMILES:
Cc1c(C(=O)Nc2ccc(F)cc2)c2CCCn2c1C(=O)C(=O)NC1(CC(F)(F)C1)c1cn(C)nn1
Structure:
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