Reaction Details Report a problem with these data
Target
Capsid protein
Ligand
BDBM473051
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
3.60±n/a nM
Citation
 Gutierrez, DA; Kobayashi, T; Lazerwith, SE; Lee, RA; Morganelli, PA; Pyun, H Substituted pyrrolizine compounds and uses thereof US Patent  US10836769 Publication Date 11/17/2020 
Target
Name:
Capsid protein
Synonyms:
C | CAPSD_HBVCJ | Core antigen | Core protein | HBcAg | p21.5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21105.01
Organism:
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C)
Description:
n/a
Residue:
183
Sequence:
MDIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
  
Inhibitor
Name:
BDBM473051
Synonyms:
US10836769, Example 37
Type:
Small organic molecule
Emp. Form.:
C24H21F5N6O3
Mol. Mass.:
536.454
SMILES:
Cc1c(C(=O)Nc2ccc(F)c(c2)C(F)F)c2CCCn2c1C(=O)C(=O)NC1(CC(F)(F)C1)c1c[nH]nn1
Structure:
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