Reaction Details Report a problem with these data
Target
Capsid protein
Ligand
BDBM473059
Substrate
n/a
Meas. Tech.
HBV DNA Quantification Assay
EC50
55.9±n/a nM
Citation
 Gutierrez, DA; Kobayashi, T; Lazerwith, SE; Lee, RA; Morganelli, PA; Pyun, H Substituted pyrrolizine compounds and uses thereof US Patent  US10836769 Publication Date 11/17/2020 
Target
Name:
Capsid protein
Synonyms:
C | CAPSD_HBVCJ | Core antigen | Core protein | HBcAg | p21.5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
21105.01
Organism:
Hepatitis B virus genotype C subtype ayr (isolate Human/Japan/Okamoto/-) (HBV-C)
Description:
n/a
Residue:
183
Sequence:
MDIDPYKEFGASVELLSFLPSDFFPSIRDLLDTASALYREALESPEHCSPHHTALRQAILCWGELMNLATWVGSNLEDPASRELVVSYVNVNMGLKIRQLLWFHISCLTFGRETVLEYLVSFGVWIRTPPAYRPPNAPILSTLPETTVVRRRGRSPRRRTPSPRRRRSQSPRRRRSQSRESQC
  
Inhibitor
Name:
BDBM473059
Synonyms:
US10836769, Example 45
Type:
Small organic molecule
Emp. Form.:
C23H23F3N4O4
Mol. Mass.:
476.4483
SMILES:
CNC(=O)C1(CC(F)(F)C1)NC(=O)C(=O)c1c(C)c(C(=O)Nc2ccc(F)cc2)c2CCCn12
Structure:
Search PDB for entries with ligand similarity: