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Target
Mitogen-activated protein kinase 1
Ligand
BDBM424925
Substrate
n/a
Meas. Tech.
Enzymatic Assay
IC50
<0.020±n/a nM
Citation
 Kolesnikov, A; Do, S Serine/threonine kinase inhibitors US Patent  US10842799 Publication Date 11/24/2020 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM424925
Synonyms:
4-(3-(4-chlorobenzyl)-4,5- dihydro-3H-1,2,2a1,5- tetraazaacenaphthylen-7-yl)- N-(1-methyl-1H-pyrazol-5- yl)pyrimidin-2-amine | US10517878, Compound I-5 | US10842799, I-5
Type:
Small organic molecule
Emp. Form.:
C23H20ClN9
Mol. Mass.:
457.918
SMILES:
Cn1nccc1Nc1nccc(n1)-c1cc2NCC(Cc3ccc(Cl)cc3)c3nnc(c1)n23
Structure:
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