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Target
Tyrosine-protein kinase SYK
Ligand
BDBM473099
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
15000±n/a nM
Citation
Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Mitchell, SA; Schmitt, AC; Xu, J; Zhao, Z Imidazopyridines Syk inhibitors US Patent US10842803 Publication Date 11/24/2020
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM473099
Synonyms:
N-[6-(1H-indazol-6-yl)- 5-methylimidazo[1,2- a]pyridin-8-yl]-5- (morpholin-4-yl)pyridin- 2-amine | US10842803, Structure TABLE 1.29
Type:
Small organic molecule
Emp. Form.:
C24H23N7O
Mol. Mass.:
425.4857
SMILES:
Cc1c(cc(Nc2ccc(cn2)N2CCOCC2)c2nccn12)-c1ccc2cn[nH]c2c1