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Target
Tyrosine-protein kinase SYK
Ligand
BDBM473116
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
20800±n/a nM
Citation
Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Mitchell, SA; Schmitt, AC; Xu, J; Zhao, Z Imidazopyridines Syk inhibitors US Patent US10842803 Publication Date 11/24/2020
More Info.:
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
Inhibitor
Name:
BDBM473116
Synonyms:
US10842803, Structure TABLE 1.46 | {1-methyl-3-[(6-{1H- pyrrolo[3,2-b]pyridin-6- yl}imidazo[1,2- a]pyridin-8-yl)amino]- 1H-pyrazol-5- yl}methanol
Type:
Small organic molecule
Emp. Form.:
C19H17N7O
Mol. Mass.:
359.3846
SMILES:
Cn1nc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)cc1CO