Target
Tyrosine-protein kinase SYK
Ligand
BDBM473116
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
20800±n/a nM
Citation
 Blomgren, PACurrie, KSKropf, JELee, SHMitchell, SASchmitt, ACXu, JZhao, Z Imidazopyridines Syk inhibitors US Patent  US10842803 Publication Date 11/24/2020 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM473116
Synonyms:
US10842803, Structure TABLE 1.46 | {1-methyl-3-[(6-{1H- pyrrolo[3,2-b]pyridin-6- yl}imidazo[1,2- a]pyridin-8-yl)amino]- 1H-pyrazol-5- yl}methanol
Type:
Small organic molecule
Emp. Form.:
C19H17N7O
Mol. Mass.:
359.3846
SMILES:
Cn1nc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)cc1CO
Structure:
Search PDB for entries with ligand similarity: