Target
Tyrosine-protein kinase SYK
Ligand
BDBM473122
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
10900±n/a nM
Citation
 Blomgren, PACurrie, KSKropf, JELee, SHMitchell, SASchmitt, ACXu, JZhao, Z Imidazopyridines Syk inhibitors US Patent  US10842803 Publication Date 11/24/2020 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM473122
Synonyms:
N-(5-(methoxymethyl)- 1-methyl-1H-pyrazol-3- yl)-6-(1H-pyrrolo[3,2- b]pyridin-6- yl)imidazo[1,2- a]pyridin-8-amine | US10842803, Structure TABLE 1.52
Type:
Small organic molecule
Emp. Form.:
C20H19N7O
Mol. Mass.:
373.4112
SMILES:
COCc1cc(Nc2cc(cn3ccnc23)-c2cnc3cc[nH]c3c2)nn1C
Structure:
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