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Target
Tyrosine-protein kinase SYK
Ligand
BDBM473137
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
92000±n/a nM
Citation
 Blomgren, PA; Currie, KS; Kropf, JE; Lee, SH; Mitchell, SA; Schmitt, AC; Xu, J; Zhao, Z Imidazopyridines Syk inhibitors US Patent  US10842803 Publication Date 11/24/2020 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM473137
Synonyms:
2-(6-(8-(5-(4- ethylpiperazin-1- yl)pyridin-2- ylamino)imidazo[1,2- a]pyridin-6-yl)-1H- indazol-3-yl)ethanol | US10842803, Structure TABLE 1.67
Type:
Small organic molecule
Emp. Form.:
C27H30N8O
Mol. Mass.:
482.5801
SMILES:
CCN1CCN(CC1)c1ccc(Nc2cc(cn3ccnc23)-c2ccc3c(CCO)n[nH]c3c2)nc1
Structure:
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