Target
Tyrosine-protein kinase SYK
Ligand
BDBM473139
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
17000±n/a nM
Citation
 Blomgren, PACurrie, KSKropf, JELee, SHMitchell, SASchmitt, ACXu, JZhao, Z Imidazopyridines Syk inhibitors US Patent  US10842803 Publication Date 11/24/2020 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM473139
Synonyms:
N-(5-(4-ethylpiperazin- 1-yl)pyridin-2-yl)-6- (1H-indazol-6-yl)-5- methylimidazo[1,2- a]pyridin-8-amine | US10842803, Structure TABLE 1.69
Type:
Small organic molecule
Emp. Form.:
C26H28N8
Mol. Mass.:
452.5541
SMILES:
CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4cn[nH]c4c3)c(C)n3ccnc23)nc1
Structure:
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