Target
Tyrosine-protein kinase SYK
Ligand
BDBM473157
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
278000±n/a nM
Citation
 Blomgren, PACurrie, KSKropf, JELee, SHMitchell, SASchmitt, ACXu, JZhao, Z Imidazopyridines Syk inhibitors US Patent  US10842803 Publication Date 11/24/2020 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM473157
Synonyms:
2-(6-(5-chloro-8-(5-(4- ethylpiperazin-1- yl)pyridin-2- ylamino)imidazo[1,2- a]pyridin-6-yl)-1- methyl-1H-indol-3- yl)ethanol | US10842803, Structure TABLE 1.87
Type:
Small organic molecule
Emp. Form.:
C29H32ClN7O
Mol. Mass.:
530.064
SMILES:
CCN1CCN(CC1)c1ccc(Nc2cc(-c3ccc4c(CCO)cn(C)c4c3)c(Cl)n3ccnc23)nc1
Structure:
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