Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM473803
Substrate
n/a
Meas. Tech.
Inhibition of Aldosterone Synthase
IC50
37.0±n/a nM
Citation
 Balestra, MBurke, JChen, ZCogan, DLord, JMarshall, DRMcKibben, BPMeyers, KMZhang, Y Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases US Patent  US10858342 Publication Date 12/8/2020 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM473803
Synonyms:
3-(1-Acetyl-1,2,3,4- tetrahydro-quinolin-6-yl)- 3,5,6,7-tetrahydro- benzoimidazol-4-one | US10858342, Compound C-AAF
Type:
Small organic molecule
Emp. Form.:
C18H19N3O2
Mol. Mass.:
309.3624
SMILES:
CC(=O)N1CCCc2cc(ccc12)-n1cnc2CCCC(=O)c12
Structure:
Search PDB for entries with ligand similarity: