Target
Cytochrome P450 11B2, mitochondrial
Ligand
BDBM473831
Substrate
n/a
Meas. Tech.
Inhibition of Aldosterone Synthase
IC50
1.30±n/a nM
Citation
 Balestra, MBurke, JChen, ZCogan, DLord, JMarshall, DRMcKibben, BPMeyers, KMZhang, Y Bicyclic imidazole derivatives useful for the treatment of renal diseases, cardiovascular diseases and fibrotic diseases US Patent  US10858342 Publication Date 12/8/2020 
Target
Name:
Cytochrome P450 11B2, mitochondrial
Synonyms:
Aldosterone Synthase (CYP11B2) | Aldosterone synthase | Aldosterone-synthesizing enzyme | C11B2_HUMAN | CYP11B2 | CYPXIB2 | Cytochrome P450 11B2 | Cytochrome P450 11B2 (CYP11B2) | Cytochrome P450 11B2, mitochondrial | P-450Aldo | P-450C18 | Steroid 18-hydroxylase
Type:
Protein
Mol. Mass.:
57582.15
Organism:
Homo sapiens (Human)
Description:
P19099
Residue:
503
Sequence:
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN
  
Inhibitor
Name:
BDBM473831
Synonyms:
2-Chloro-4-(5,5-dimethyl-7- oxo-4,5,6,7-tetrahydro- benzoimidazol-1-yl)- benzonitrile | US10858342, Compound C-ABE
Type:
Small organic molecule
Emp. Form.:
C16H14ClN3O
Mol. Mass.:
299.755
SMILES:
CC1(C)Cc2ncn(c2C(=O)C1)-c1ccc(C#N)c(Cl)c1
Structure:
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