Reaction Details Report a problem with these data
Target
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Ligand
BDBM473976
Substrate
n/a
Meas. Tech.
dUTPase Inhibition
IC50
2500±n/a nM
Citation
 Spyvee, M Hydantoin containing deoxyuridine triphosphatase inhibitors US Patent  US10858344 Publication Date 12/8/2020 
Target
Name:
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Synonyms:
DUT | DUT_HUMAN | Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) | Deoxyuridine triphosphatase (dUTPase) | dUTP pyrophosphatase
Type:
Enzyme
Mol. Mass.:
26574.03
Organism:
Homo sapiens (Human)
Description:
P33316
Residue:
252
Sequence:
MTPLCPRPALCYHFLTSLLRSAMQNARGARQRAEAAVLSGPGPPLGRAAQHGIPRPLSSAGRLSQGCRGASTVGAAGWKGELPKAGGSPAPGPETPAISPSKRARPAEVGGMQLRFARLSEHATAPTRGSARAAGYDLYSAYDYTIPPMEKAVVKTDIQIALPSGCYGRVAPRSGLAAKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERIFYPEIEEVQALDDTERGSGGFGSTGKN
  
Inhibitor
Name:
BDBM473976
Synonyms:
US10858344, Example 84
Type:
Small organic molecule
Emp. Form.:
C22H30FN3O6S
Mol. Mass.:
483.554
SMILES:
CC[C@@](O)(CNS(=O)(=O)C\C=C\CN1CC(=O)NC1=O)c1ccc(F)c(OCC2CCC2)c1 |r|
Structure:
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