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Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Ligand
BDBM474185
Substrate
n/a
Meas. Tech.
PDE1 Inhibition Assay
IC50
6.00±n/a nM
Citation
 Kehler, J; Rasmussen, LK; Langgård, M; Jessing, M; Juhl, K; Vital, PJ Imidazopyrazinones as PDE1 inhibitors US Patent  US10858362 Publication Date 12/8/2020 
Target
Name:
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B
Synonyms:
63 kDa Cam-PDE | Calcium/calmodulin-dependent 3 ,5 -cyclic nucleotide phosphodiesterase 1B | Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B | Cam-PDE 1B | PDE1B | PDE1B1 | PDE1B_HUMAN | PDES1B | Phosphodiesterase 1B | Phosphodiesterase 1B (PDE1B1) | Phosphodiesterase Type 1 (PDE1B) | Phosphodiesterase, PDE1/PDE5
Type:
Enzyme
Mol. Mass.:
61366.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
536
Sequence:
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
  
Inhibitor
Name:
BDBM474185
Synonyms:
6-methyl-7-(((trans)-4- methylcyclohexyl)methyl)-3- (tetrahydro-2H-pyran-4- yl)imidazo[1,5-a]pyrazin-8(7H)- one | US10858362, Example 66--cis | US10858362, Example 66--trans
Type:
Small organic molecule
Emp. Form.:
C20H29N3O2
Mol. Mass.:
343.4632
SMILES:
CC1CCC(Cn2c(C)cn3c(ncc3c2=O)C2CCOCC2)CC1 |(-6.54,-.23,;-5.21,.54,;-5.21,2.08,;-3.88,2.85,;-2.54,2.08,;-1.21,2.85,;.13,2.08,;.13,.54,;-1.21,-.23,;1.46,-.23,;2.79,.54,;4.26,.07,;5.16,1.31,;4.26,2.56,;2.79,2.08,;1.46,2.85,;1.46,4.39,;4.66,-1.42,;3.57,-2.51,;3.97,-4,;5.45,-4.39,;6.54,-3.31,;6.14,-1.82,;-2.54,.54,;-3.88,-.23,)|
Structure:
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