Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM474315
Substrate
n/a
Meas. Tech.
FLIPR and cAMP Inhibition Assay
IC50
1.000±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US10858365 Publication Date 12/8/2020 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_MOUSE | Adenosine A2a receptor | Adenosine receptor A2a | Adora2a
Type:
PROTEIN
Mol. Mass.:
44984.04
Organism:
Mus musculus
Description:
ChEMBL_479903
Residue:
410
Sequence:
MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPS
  
Inhibitor
Name:
BDBM474315
Synonyms:
7-(4-fluorophenyl)-8-(3-methylimidazo[1,2-a] pyridin-6-yl)-2-((tetrahydrofuran-3-yl)methyl)-[l,2, 4]triazolo[1,5-c]pyrimidin-5-amine(isomer 1) | US10858365, Compound 105-1
Type:
Small organic molecule
Emp. Form.:
C24H22FN7O
Mol. Mass.:
443.4762
SMILES:
Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(CC3CCOC3)nc12)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: