Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM474329
Substrate
n/a
Meas. Tech.
FLIPR and cAMP Inhibition Assay
IC50
0.200±n/a nM
Citation
 Zeng, Q; Qi, C; Tsui, H; Yang, Z; Zhang, X Triazolo-pyrimidine compounds and uses thereof US Patent  US10858365 Publication Date 12/8/2020 
Target
Name:
Adenosine receptor A2a
Synonyms:
AA2AR_MOUSE | Adenosine A2a receptor | Adenosine receptor A2a | Adora2a
Type:
PROTEIN
Mol. Mass.:
44984.04
Organism:
Mus musculus
Description:
ChEMBL_479903
Residue:
410
Sequence:
MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPS
  
Inhibitor
Name:
BDBM474329
Synonyms:
7-(3-fluoro-1H-pyrazol-1-yl)-2-((3-fluoropyridin- 2-yl)methyl)-8-(3-methylimidazo[l,2-a]pyridin- 6-yl)-[l,2,4]triazolo[l,5-c]pyrimidin-5-amine | US10858365, Compound 116
Type:
Small organic molecule
Emp. Form.:
C22H16F2N10
Mol. Mass.:
458.4262
SMILES:
Cc1cnc2ccc(cn12)-c1c(nc(N)n2nc(Cc3ncccc3F)nc12)-n1ccc(F)n1
Structure:
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