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Target
Polymerase acidic protein
Ligand
BDBM474359
Substrate
n/a
Meas. Tech.
Endonuclease Inhibition Assay (PA FP Assay)
IC50
20.0±n/a nM
Citation
 Jain, R; Koester, DC; Manning, JR; Sutton, JC; Taft, BR; Wan, L; Zhao, Q Tricyclic compounds useful to treat orthomyxovirus infections US Patent  US10858366 Publication Date 12/8/2020 
Target
Name:
Polymerase acidic protein
Synonyms:
PA | PA_I75A3 | RNA-directed RNA polymerase subunit P2
Type:
Protein
Mol. Mass.:
82806.72
Organism:
n/a
Description:
P31343
Residue:
716
Sequence:
MEDFVRQCFNPMIVELAEKAMKEYGEDLKIETNKFAAICTHLEVCFMYSDFHFINEQGESIVVELDDPNALLKHRFEIIEGRDRTMAWTVVNSICNTTGAEKPKFLPDLYDYKENRFIEIGVTRREVHIYYLEKANKIKSENTHIHIFSFTGEGMATKADYTLDEESRARIKTRLFTIRQEMANRGLWDSFRQSERGEETIEERFEITGTMRRLADQSLPPNFSCLENFRAYVDGFEPNGCIEGKLSQMSKEVNAKIEPFLKTTPRPIKLPDGPPCFQRSKFLLMDALKLSIEDPSHEGEGIPLYDAIKCMRTFFGWKEPYIVKPHERGINSNYLLSWKQVLAELQDIENEEKIPRTKNMKKTSQLKWALGENMAPEKVDFDNCRDISDLKQYDSDEPELRSLSSWIQNEFNKACELTDSIWIELDEIGEDVAPIEYIASMRRNYFTAEVSHCRATEYIMKGVYINTALLNASCAAMDDFQLIPMISKCRTKEGRRKTNLYGFIIKGRSHLRNDTDVVNFVSMEFSLTDPRLEPHKWEKYCVLEIGDMLLRSAIGQMSRPMFLYVRTNGTSKIKMKWGMEMRRCLLQSLQQIESMIEAESSVKEKDMTKEFFENKSETWPIGESPKGVEEGSIGKVCRTLLAKSVFNSLYASPQLEGFSAESRKLLLVVQALRDNLEPGTFDLGGLYEAIEECLINDPWVLLNASWFNSFLTHALR
 
Inhibitor
Name:
BDBM474359
Synonyms:
3-((S)-(4-fluorophenyl)((S)-11-hydroxy-10- oxo-5,6-dihydro-10H- imidazo[2',1':3,4]pyrazino[1,2-b]pyridazin-6- yl)methyl)benzonitrile | US10858366, Example 43 | US11453677, Example 43
Type:
Small organic molecule
Emp. Form.:
C23H16FN5O2
Mol. Mass.:
413.4038
SMILES:
Oc1c2-c3nccn3C[C@H]([C@@H](c3ccc(F)cc3)c3cccc(c3)C#N)n2ncc1=O |r|
Structure:
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