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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM474381
Substrate
n/a
Meas. Tech.
Radiolabel Binding Studies for Serotonin 5HT7 Receptors
IC50
18.0±n/a nM
Citation
 Canney, DJ; Blass, BE; Blattner, KM; Pippin, DA Modulators of the 5-hydroxytryptamine receptor 7 and their method of use US Patent  US10858368 Publication Date 12/8/2020 
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM474381
Synonyms:
US10858368, Entry 1 | US11319327, Entry 1
Type:
Small organic molecule
Emp. Form.:
C28H37N3O2
Mol. Mass.:
447.6123
SMILES:
Cc1ccc(cc1)N1CCN(CCC2CC3(CCN(Cc4ccccc4)CC3)C(=O)O2)CC1
Structure:
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