Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM474407
Substrate
n/a
Meas. Tech.
MAGL Enzymatic Assay (30 minute)
IC50
136±n/a nM
Citation
 Brodney, MA; Butler, CR; McAllister, LA; Helal, CJ; O''Neil, SV; Verhoest, PR Heterocyclic spiro compounds as MAGL inhibitors US Patent  US10858373 Publication Date 12/8/2020 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM474407
Synonyms:
1-{[(4-Benzyl-1-oxa-4,9-diazaspiro[5.5]undec-9-yl)carbonyl]oxy}pyrrolidine-2,5-dione | US10858373, Example 5
Type:
Small organic molecule
Emp. Form.:
C20H25N3O5
Mol. Mass.:
387.4296
SMILES:
O=C(ON1C(=O)CCC1=O)N1CCC2(CC1)CN(Cc1ccccc1)CCO2
Structure:
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