Reaction Details Report a problem with these data
Target
Monoglyceride lipase
Ligand
BDBM474410
Substrate
n/a
Meas. Tech.
MAGL Enzymatic Assay (0 minute)
IC50
35.0±n/a nM
Citation
 Brodney, MA; Butler, CR; McAllister, LA; Helal, CJ; O''Neil, SV; Verhoest, PR Heterocyclic spiro compounds as MAGL inhibitors US Patent  US10858373 Publication Date 12/8/2020 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM474410
Synonyms:
1,1,1,3,3,3-Hexafluoropropan-2-yl 2-benzoyl-2,8-diazaspiro[4.5]decane-8-carboxylate | US10858373, Example 8
Type:
Small organic molecule
Emp. Form.:
C19H20F6N2O3
Mol. Mass.:
438.3641
SMILES:
FC(F)(F)C(OC(=O)N1CCC2(CCN(C2)C(=O)c2ccccc2)CC1)C(F)(F)F
Structure:
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