Target
Monoglyceride lipase
Ligand
BDBM474427
Substrate
n/a
Meas. Tech.
MAGL Enzymatic Assay (0 minute)
IC50
1320±n/a nM
Citation
 Brodney, MAButler, CRMcAllister, LAHelal, CJO''Neil, SVVerhoest, PR Heterocyclic spiro compounds as MAGL inhibitors US Patent  US10858373 Publication Date 12/8/2020 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM474427
Synonyms:
US10858373, Example 25
Type:
Small organic molecule
Emp. Form.:
C20H24FN3O5
Mol. Mass.:
405.4201
SMILES:
Fc1ccc(CN2CCOC3(CCN(CC3)C(=O)ON3C(=O)CCC3=O)C2)cc1
Structure:
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