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Target
Ataxin-1
Ligand
BDBM475813
Substrate
n/a
Meas. Tech.
Enzyme Inhibition Assay
IC50
17.0±n/a nM
Citation
 Mattei, P; Hunziker, D; Di Giorgio, P; Hert, J; Rudolph, M; Wang, L Octahydro-cyclobuta[1,2-c;3,4-c′]dipyrrol-2-yl US Patent  US10849881 Publication Date 12/1/2020 
Target
Name:
Ataxin-1
Synonyms:
ATX1 | ATX1_HUMAN | ATXN1 | SCA1
Type:
Protein
Mol. Mass.:
86941.25
Organism:
Homo sapiens (Human)
Description:
P54253
Residue:
815
Sequence:
MKSNQERSNECLPPKKREIPATSRSSEEKAPTLPSDNHRVEGTAWLPGNPGGRGHGGGRHGPAGTSVELGLQQGIGLHKALSTGLDYSPPSAPRSVPVATTLPAAYATPQPGTPVSPVQYAHLPHTFQFIGSSQYSGTYASFIPSQLIPPTANPVTSAVASAAGATTPSQRSQLEAYSTLLANMGSLSQTPGHKAEQQQQQQQQQQQQHQHQQQQQQQQQQQQQQHLSRAPGLITPGSPPPAQQNQYVHISSSPQNTGRTASPPAIPVHLHPHQTMIPHTLTLGPPSQVVMQYADSGSHFVPREATKKAESSRLQQAIQAKEVLNGEMEKSRRYGAPSSADLGLGKAGGKSVPHPYESRHVVVHPSPSDYSSRDPSGVRASVMVLPNSNTPAADLEVQQATHREASPSTLNDKSGLHLGKPGHRSYALSPHTVIQTTHSASEPLPVGLPATAFYAGTQPPVIGYLSGQQQAITYAGSLPQHLVIPGTQPLLIPVGSTDMEASGAAPAIVTSSPQFAAVPHTFVTTALPKSENFNPEALVTQAAYPAMVQAQIHLPVVQSVASPAAAPPTLPPYFMKGSIIQLANGELKKVEDLKTEDFIQSAEISNDLKIDSSTVERIEDSHSPGVAVIQFAVGEHRAQVSVEVLVEYPFFVFGQGWSSCCPERTSQLFDLPCSKLSVGDVCISLTLKNLKNGSVKKGQPVDPASVLLKHSKADGLAGSRHRYAEQENGINQGSAQMLSENGELKFPEKMGLPAAPFLTKIEPSKPAATRKRRWSAPESRKLEKSEDEPPLTLPKPSLIPQEVKICIEGRSNVGK
  
Inhibitor
Name:
BDBM475813
Synonyms:
(1H-benzotriazol-5-yl)- [(3aS,3bR,6aS,6bR)-5-(5-chloro-4- cyclopropylmethoxy-pyridine-2-carbonyl)- octahydro-cyclobuta[1,2-c;3,4-c']dipyrrol- 2-yl]-methanone | US10849881, Example 1.086
Type:
Small organic molecule
Emp. Form.:
C25H25ClN6O3
Mol. Mass.:
492.957
SMILES:
Clc1cnc(cc1OCC1CC1)C(=O)N1C[C@H]2[C@@H]3CN(C[C@@H]3[C@H]2C1)C(=O)c1ccc2[nH]nnc2c1 |r|
Structure:
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