Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM474727
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
<1000±n/a nM
Citation
 Kotian, PL; Babu, YS; Zhang, W; Vogeti, L; Wu, M; Chintareddy, VR; Raman, K Benzopyrazole compounds and analogues thereof US Patent  US10849883 Publication Date 12/1/2020 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM474727
Synonyms:
US10849883, Compound 155d | US11559515, Compound 155d
Type:
Small organic molecule
Emp. Form.:
C23H24ClFN4O3
Mol. Mass.:
458.913
SMILES:
CC(C)N(CC(=O)NCc1cccc(Cl)c1F)C(=O)Cn1nc(C(C)=O)c2ccccc12
Structure:
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