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Target
ADP-ribosylation factor 6
Ligand
BDBM475015
Substrate
n/a
Meas. Tech.
Biochemical Assay1
IC50
4.90±n/a nM
Citation
 Ostanin, K; Shenderovich, M; Bajji, A; Cioffi, CL; Moss, N; Vankayalapati, H; Li, D Arf6 inhibitors and methods of synthesis and use thereof US Patent  US10849901 Publication Date 12/1/2020 
Target
Name:
ADP-ribosylation factor 6
Synonyms:
ARF6 | ARF6_HUMAN
Type:
Protein
Mol. Mass.:
20087.47
Organism:
Human
Description:
P62330
Residue:
175
Sequence:
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
  
Inhibitor
Name:
BDBM475015
Synonyms:
US10849901, Compound 65
Type:
Small organic molecule
Emp. Form.:
C20H13ClF3N3O
Mol. Mass.:
403.785
SMILES:
FC(F)(F)c1nn2c([nH]c(Cc3ccccc3)cc2=O)c1-c1ccc(Cl)cc1
Structure:
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