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Target
ADP-ribosylation factor 6
Ligand
BDBM475083
Substrate
n/a
Meas. Tech.
Biochemical Assay
IC50
13.0±n/a nM
Citation
 Ostanin, K; Shenderovich, M; Bajji, A; Cioffi, CL; Moss, N; Vankayalapati, H; Li, D Arf6 inhibitors and methods of synthesis and use thereof US Patent  US10849901 Publication Date 12/1/2020 
Target
Name:
ADP-ribosylation factor 6
Synonyms:
ARF6 | ARF6_HUMAN
Type:
Protein
Mol. Mass.:
20087.47
Organism:
Human
Description:
P62330
Residue:
175
Sequence:
MGKVLSKIFGNKEMRILMLGLDAAGKTTILYKLKLGQSVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEARQELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRNWYVQPSCATSGDGLYEGLTWLTSNYKS
  
Inhibitor
Name:
BDBM475083
Synonyms:
US10849901, Compound 133
Type:
Small organic molecule
Emp. Form.:
C25H17ClN6O4
Mol. Mass.:
500.893
SMILES:
Cc1cc(nc2cc(nn12)C(=O)Nc1cc(Oc2cncc(Cl)c2)cc(c1)[N+]([O-])=O)-c1ccccc1
Structure:
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