Reaction Details Report a problem with these data
Target
Egl nine homolog 1 [181-417]
Ligand
BDBM475549
Substrate
n/a
Meas. Tech.
Enzyme Activity Assay
IC50
25.1±n/a nM
Citation
 Hocutt, FM; Leonard, Jr., BE; Peltier, HM; Phuong, VK; Rabinowitz, MH; Rosen, MD; Tarantino, KT; Venkatesan, H; Zhao, LX Benzoimidazoles as prolyl hydroxylase inhibitors US Patent  US10851083 Publication Date 12/1/2020 
Target
Name:
Egl nine homolog 1 [181-417]
Synonyms:
C1orf12 | EGLN1 | EGLN1_HUMAN | Egl nine homolog 1 (aa 181-417)
Type:
Enzyme
Mol. Mass.:
26555.51
Organism:
Homo sapiens (Human)
Description:
aa 181-417
Residue:
237
Sequence:
PNGQTKPLPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTDGQLVSQKSDSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKINGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGILRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFDADERARAKVKYLTGEKGVRVELNKP
  
Inhibitor
Name:
BDBM475549
Synonyms:
1-(5-Benzenesulfonyl-6-trifluoromethyl-1H- | US10851083, Example 161 | US11618744, Example 161
Type:
Small organic molecule
Emp. Form.:
C18H11F3N4O4S
Mol. Mass.:
436.365
SMILES:
OC(=O)c1cnn(c1)-c1nc2cc(c(cc2[nH]1)C(F)(F)F)S(=O)(=O)c1ccccc1
Structure:
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