Reaction Details Report a problem with these data
Target
Macrophage metalloelastase
Ligand
BDBM475579
Substrate
n/a
Meas. Tech.
Inhibitory Assay
IC50
2750±n/a nM
Citation
 Yang, W; Chang, K; Liu, S; Tsai, C Matrix metalloproteinase (MMP) inhibitors and methods of use thereof US Patent  US10851089 Publication Date 12/1/2020 
Target
Name:
Macrophage metalloelastase
Synonyms:
HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12)
Type:
Enzyme
Mol. Mass.:
54012.99
Organism:
Homo sapiens (Human)
Description:
P39900
Residue:
470
Sequence:
MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
  
Inhibitor
Name:
BDBM475579
Synonyms:
US10851089, Compound FC-9
Type:
Small organic molecule
Emp. Form.:
C23H22N2O4S
Mol. Mass.:
422.497
SMILES:
CCC1(NC(=O)NC1=O)c1occc1Sc1ccc(OCc2cccc(C)c2)cc1
Structure:
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